Formulation and In-Vitro Evaluation of Eplerenone Fast Disintegrating Tablets by Solid Dispersion technique

نویسندگان

چکیده

Eplerenone, a BCS class II drug with low bioavailability and t1/2 of 3-6 hrs is primarily used to treat Congestive Heart Failure (CHF) hypertension. So, develop the biological performance solid dispersion along oral disintegrates was prepared by employing HP ?-Cyclodextrin ?-Cyclodextrin. Eplerenone dispersions were repared various carriers in varying ratios carrier respectively (0.5:1, 1:1 1.5:1). Results through solvent evaporation technique demonstrated which comprise melti g point determination, solubility, entrapment efficiency, content uniformness in-vitro breakup studies. Characterization state done FT-IR. From comparison all formulation characteristics, (F3) containing + Hp ?-cyclodextrin (1:1.5) showed better results y technique. As maximum released from F3 at end 60 min, this decided as best. optimized formulation, Fast dissolving tablets formulated concentrations. The pre post compression parameters calculated pecified. All within acceptable range. An discharge study victimisation pH 6.8 buffers. F6 crospovidone (13.5mg) exhibited 97.36 % release 20mins. follows zero-order kinetics.

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ژورنال

عنوان ژورنال: Future Journal of Pharmaceuticals and Health Sciences

سال: 2021

ISSN: ['2583-116X']

DOI: https://doi.org/10.26452/fjphs.v1i2.227